FDA-approved to treat adults with plaque psoriasis²

VTAMA is the first and only aryl hydrocarbon receptor (AhR) agonist indicated for the treatment of plaque psoriasis

The Role of AhR

First-in-Class Tapinarof

The role of AhR agonism

Activation of the AhR has been shown to support normalization of skin barrier function. AhR is highly expressed in epithelial and immune cells of barrier tissues, including the skin, gastrointestinal tract, and lungs. AhR activation can promote the following^1-3:

Scales

A balanced immune response by reducing proinflammatory cytokines.^1,4,5

Skin barrier restoration through increased expression of genes that encode skin barrier proteins, such as filaggrin, and genes involved in ceramide production.^1,3,5,6

Tapinarof activates AhR
which regulates pathways involved in plaque psoriasis¹

In preclinical studies, tapinarof was shown to decrease proinflammatory cytokines and increase expression of genes that encode skin barrier proteins, such as filaggrin, and genes that are involved in lipid production, such as ceramides. This may lead to an anti-inflammatory effect and potential skin barrier restoration.^1,3,5,6

The specific mechanisms by which VTAMA exerts its therapeutic actions are unknown.

Scales

Anti-inflammatory activity

Through reduction of inflammatory Th17 cytokines involved in plaque psoriasis (as demonstrated in ex vivo, in vitro, and mouse models)^1,5

Potential skin barrier restoration

Through increased expression of genes that encode skin barrier proteins and genes that are involved in lipid production (as demonstrated in vitro)^1,5,6

Th, T helper.

Efficacy

Learn more about the significant treatment success rate of VTAMA vs vehicle

Find out more

References: 1. Organon DOF [MyVTAMA Pharmacy Count; Jan 2023]. 2. VTAMA (tapinarof) cream, 1%. Prescribing Information. Organon; 2022. 3. Strober B, Stein Gold L, Bissonnette R, et al. One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: results from the PSOARING 3 trial. J Am Acad Dermatol. 2022;87(4):800-806. 4. Stein Gold L, Kircik L, Lebwohl M, et al. Tapinarof cream 1% once daily for plaque psoriasis: favorable local tolerability in two pivotal phase 3 trials. Poster presented at: Innovations in Dermatology Conference; March 16–20, 2021; virtual. 5. Lebwohl M, Stein Gold L, Strober B, et al. Phase 3 trials of tapinarof cream for plaque psoriasis. N Engl J Med. 2021;385(24):2219-2229. 6. Organon DOF. CSR-DMVT-505-3001. A phase 3 efficacy and safety study of tapinarof for the treatment of plaque psoriasis in adults. 2020. 7. Organon DOF. CSR-DMVT-505-3002. A phase 3 efficacy and safety study of tapinarof for the treatment of plaque psoriasis in adults. 2020. 8. Stein Gold L, Blauvelt A, Armstrong A, et al. Tapinarof cream 1% once daily for plaque psoriasis: secondary efficacy outcomes from two pivotal phase 3 trials. Poster presented at: International Federation of Psoriasis Associations; June 30–July 3, 2021; virtual. 9. Organon DOF. PSOARING Patient Images. 2022. 10. Bissonnette R, Strober B, Lebwohl M, et al. Tapinarof cream 1% once daily for plaque psoriasis: patient-reported outcomes from two pivotal phase 3 trials. Poster presented at: American Academy of Dermatology; March 19–23, 2021; San Francisco, CA. 11. Organon DOF. CSP-DMVT-505-3001. A phase 3 efficacy and safety study of tapinarof for the treatment of plaque psoriasis in adults. 2019. 12. Bissonnette R, Stein Gold L, Rubenstein DS, Tallman AM, Armstrong A. Tapinarof in the treatment of psoriasis: a review of the unique mechanism of action of a novel therapeutic aryl hydrocarbon receptor—modulating agent. J Am Acad Dermatol. 2021;84(4):1059-1067. 13. Smith SH, Jayawickreme C, Rickard DJ, et al. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans. J Invest Dermatol. 2017;137:2110-2119. 14. Greb JE, Goldminz AM, Elder JT, et al. Psoriasis. Nat Rev Dis Primers. 2016;2:16082. 15. Rendon A, Schäkel K. Psoriasis pathogenesis and treatment. Int J Mol Sci. 2019;20(6):1475. 16. Kim BE, Howell MD, Guttman E, et al. TNF-α downregulates filaggrin and loricrin through c-Jun N-terminal kinase: role for TNF-α antagonists to improve skin barrier. J Invest Dermatol. 2011;131:1272-1279. 17. Cannavò SP, Riso G, Casciaro M, Di Salvo E, Gangemi S. Oxidative stress involvement in psoriasis: a systematic review. Free Radic Res. 2019;53(8):829-840. 18. Dietrich C. Antioxidant functions of the aryl hydrocarbon receptor. Stem Cell Int. 2016:7943495. 19. Organon DOF. The effect of GSK2894512 on the Th2 polarization of human CD4+ T cells and on IL-8 release from TLR2-stimulated keratinocytes. 2015. 20. Bissonnette R, Poulin Y, Zhou Y, et al. Efficacy and safety of topical WBI-1001 in patients with mild to severe atopic dermatitis: results from a 12-week multicentre, randomized, placebo-controlled double-blind trial. Br J Derm. 2012;166(4):853-860. 21. Bagel J, Stein Gold L, Del Ross J, et al. Tapinarof cream 1% once daily for the treatment of plaque psoriasis: Patient-reported outcomes from the PSOARING 3 trial. J Am Acad Dermatol. 2023;89:936-44. 22. Organon DOF. GSK2894512A: Formulation Development Report. 2018. 23. Sofen H, Tyring S, Johnson SM, et al. Efficacy of tapinarof cream 1% once daily for the treatment of mild to severe intertriginous plaque psoriasis. Poster presented at: Fall Clinical Dermatology Conference; October 19-22, 2023; Las Vegas, NV. 24. Sofen H, Tyring S, Johnson SM, et al. Tapinarof cream 1% once daily improves patient-reported outcomes in the treatment of mild to severe intertriginous plaque psoriasis. Poster presented at: Fall Clinical Dermatology Conference; October 19-22, 2023; Las Vegas, NV. 25. Organon DOF. DMVT-505-4001 iPsO Patient Images. 2023 26. Strober B, Stein Gold L, Bissonnette R, et al. One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial. J Am Acad Dermatol. 2022; 87:800-806. 27. Organon DOF. CSR-DMVT-505-3003. A long-term, open-label extension study to evaluate the safety and efficacy of tapinarof cream, 1% for the treatment of plaque psoriasis in adults. 2021. 28. Organon DOF. PSOARING 3 entering with or achieving PGA 0 or 1; Jan 2024. 29. Stein Gold L, Lewitt GM, Lockshin B, et al. Tapinarof cream 1% once daily is efficacious in the treatment of mild to severe plaque psoriasis in the head and neck region. Poster presented at: Winter Clinical Dermatology Conference; January 12-17, 2024; Honolulu, HI. 30. Lewitt GM, Stein Gold L, Lockshin B, et al. Tapinarof 1% cream improves patient-reported outcomes in the treatment of mild to severe plaque psoriasis in the head and neck region. Poster presented at: Winter Clinical Dermatology Conference; January 12-17, 2024; Honolulu, HI. 31. Organon DOF. 4002 Head & Neck Plaque Psoriasis Phase 4. 2023.

robert

Not an actual patient

Emily, 51

Your active and public-facing patient

carlos

Emily, 51

Not an actual patient

Your active and public‑facing patient

• Works in a public-facing job and is self-conscious about her appearance when having a plaque psoriasis flare

• Has mild plaque psoriasis and is not a candidate for biologics

Her plaques affect 3% of her body surface area (BSA), but they are concentrated around her face and neck
She has a PGA score of 2 (mild)

• Cycled through different over-the-counter steroid creams, which did not give her the results she was looking for

• Does a lot of research but relies on her dermatologist for her best options

Emily’s Treatment Needs^3-5

A non-steroidal topical option that is safe in sensitive areas like her face and neck
VTAMA cream could be a good option because it’s well tolerated in sensitive areas and delivers significantly clearer skin

View tolerability

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PSOARING 3 Study Design

Follow-up every 4 weeks, regardless of treatment group³
Off treatment: patients who entered the open-label LTE with or achieved PGA=0 during the open-label LTE had VTAMA cream treatment temporarily discontinued³
On treatment: patients entering the open-label LTE with PGA≥1 or with disease worsening during the LTE (PGA≥2) were treated with VTAMA cream until PGA=0 was achieved (or week 40)³

Follow-up every 4 weeks, regardless of treatment group³
Off treatment: patients who entered the open-label LTE or achieved PGA=0 during the open-label LTE had VTAMA cream treatment temporarily discontinued³
On treatment: patients entering the open-label LTE with PGA≥1 or with disease worsening during the LTE (PGA≥2) were treated with VTAMA cream until PGA=0 was achieved (or week 40)³

LTE, long-term extension.
*Patients electing not to participate in the open-label LTE had a follow-up visit 4 weeks after completion of their treatment period.
^†Four patients (3 on VTAMA cream, 1 on vehicle) did not have a baseline PGA and are listed as missing.

References: 1. Strober B, Stein Gold L, Bissonnette R, et al. One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: results from the PSOARING 3 trial. J Am Acad Dermatol. 2022;87(4):800-806. 2. Lebwohl MG, Stein Gold L, Strober B, et al. Phase 3 trials of tapinarof cream for plaque psoriasis. N Engl J Med. 2021;385(24):2219-2229. 3. Strober B, Gold L, Bissonnette R, et al. One-year safety and efficacy of tapinarof cream for the treatment of plaque psoriasis: Results from the PSOARING 3 trial. Supplementary materials. J Am Acad Dermatol. 2022;87(4):800-806.