VTAMA cream is a once-daily, steroid-free, prescription topical treatment for atopic dermatitis in patients down to 2 years of age. It is also indicated for adults with plaque psoriasis. It is a first-in-class topical Aryl hydrocarbon receptor (AhR) agonist that was approved for adult plaque psoriasis by the FDA in May 2022 and for atopic dermatitis in adults and patients 2 years old and older in December 2024.^1,2

VTAMA cream is a steroid-free topical treatment indicated for patients down to 2 years of age with atopic dermatitis. It is also approved for adults with plaque psoriasis.^1,2

VTAMA cream should be stored at 20°C to 25°C (68°F to 77°F), with excursions permitted between 15°C and 30°C (59°F and 86°F).¹

VTAMA cream should be kept out of reach of children.¹

It should not be frozen or exposed to excessive heat.¹

VTAMA cream is a well-tolerated treatment option for atopic dermatitis in patients down to 2 years of age with no restrictions on topical external use to affected areas. It can even be used on sensitive skin areas, including the face, neck, underarm, under the breast areas, genital area, and gluteal cleft. VTAMA cream is not for oral, ophthalmic, or intravaginal use.^1,6

Learn more about tolerability of VTAMA cream here.

A thin layer of VTAMA cream should be applied only to the affected areas once daily. Avoid applying VTAMA cream to unaffected areas of skin.¹

After applying VTAMA cream, patients should wash their hands (unless the affected area is on the hands). If someone else helps apply it, they should wash their hands when finished.¹

VTAMA cream is not for oral, ophthalmic, or intravaginal use.¹

In clinical studies, the most common adverse reactions (occurring in ≥1% of patients with atopic dermatitis in both pivotal 8-week studies) were upper respiratory tract infection, folliculitis, lower respiratory tract infection, headache, asthma, vomiting, ear infection, pain in extremity, and abdominal pain.¹

You can learn more about the safety profile of VTAMA cream here.

VTAMA cream was studied in 2 identical 8-week pivotal studies as well as a 48-week, open-label, long-term extension study.²

The pivotal studies (ADORING 1 and ADORING 2) were double-blind, vehicle-controlled studies in more than 800 patients down to 2 years of age with moderate to severe atopic dermatitis.²

The open-label long-term extension study (ADORING 3) was designed to evaluate the safety and efficacy for 48 weeks. This study included mild, moderate, and severe patients from ADORING 1, ADORING 2, the MUPK study, as well as patients who were directly enrolled.⁵

You can learn more about the efficacy of VTAMA cream here.

VTAMA cream was not studied in patients who were pregnant or breastfeeding. There are insufficient data available to evaluate drug-associated risks of major birth defects, miscarriage, or other maternal or fetal outcomes. No data are available regarding the presence of tapinarof in human milk or the effects of tapinarof on breastfed infants or on milk production.¹

AhR is a ligand-dependent transcription factor that is present in several tissues of the body, including the skin.¹⁰

Activation of AhR by tapinarof helps:

• Skin barrier restoration through upregulation of skin barrier proteins such as filaggrin, loricrin, involucrin, and ceramides, as demonstrated in vitro^2,10-12
• Reduction of Th2 cytokines (IL-4, IL-5, IL-13, IL-31), as demonstrated in vitro and in mice models^2,10,13,14
• Increase antioxidant activity via induction of the Nrf2 pathway, as demonstrated in vitro and ex vivo^10,11

Dermavant is committed to making our medications accessible and affordable. With the MyVTAMA™ Savings Card, commercially insured patients may pay as little as $0 and no more than $35.*

Additional resources, including the Patient Brochure, are available to help patients get the most of their treatment.

*Eligibility required. This offer is invalid for patients whose prescription claims are eligible to be reimbursed, in whole or in part, by any governmental program.